DISCUSS HOW GLYCOGEN IS SYNTHESISED GENERAL STRUCTURE INFORMATION Glycogen comprises polymers of glucose, linked by á 1-4 glycosidic bonds. The branch points are linked by á 1-6 glycosidic bonds. The branch points occur at 8, 9 or 10 residue spacings along the linear chain. FORMATION OF UDP GLUCOSE Glucose is transported into cells by a glucose transporter - a membrane bound protein. It is phosphorylated to form glucose-6-phosphate. This is catalysed by hexokinase. ATP is converted to ADP, which …showed first 75 words of 782 total…

…showed last 75 words of 782 total…gt; 1mM, the D-form is active. This is because glucose-6-phosphate is an allosteric effector -by binding to a particular site on the synthase enzyme it increases the affinity of the enzyme for its substrate - UDP glucose. The de-phosphorylated version, glycogen synthase I, is the active form of the enzyme. This version predominates in resting muscle. It catalyses the addition of glucose residues to the glycogen polymers, independent to the concentration of glucose-6-phosphate.